Progressive Supranuclear Palsy (PSP) is a rare brain disorder that causes serious and permanent problems with gait and balance. Loss of balance while walking is often the most frequent first symptom of PSP. The most noticeable characteristic of PSP is the inability to aim the eyes properly (or “palsy”), particularly in the downward direction. This is caused by the occurrence of lesions in the areas of the brain which coordinate eye movements.

Symptoms typically begin in one’s 60’s but there have been documented cases with symptoms presenting in one’s 40’s. PSP is often misdiagnosed as Parkinson’s disease due to its general slowing of movement. It is also mistaken as Alzheimer’s disease because of its changes in mood, personality, and cognitive functioning.

• Loss of balance while walking
• Inability to control eye movements
• Increased irritability
• Sleep disturbances
• Slurred speech
• Forgetfulness
• Apathy
• Difficulty with abstract reasoning

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There is currently no effective medication for PSP itself, however, drugs that may have some benefit are anti-Parkinsonian agents or anti-depressant medications.

There is also non-drug treatment for PSP.  Patients frequently elect to use weighted walking aids, which help in stabilizing balance.  Bifocals or special glasses called prisms are sometimes prescribed for PSP patients to remedy visual difficulties.  Also, formal physical therapy may be used to keep limbs flexible and retain their full range of motion.

More information

Progressive Supranuclear Palsy Information Page: National Institute of Neurological Disorders and Stroke (NINDS)
http://www.ninds.nih.gov/disorders/psp/psp.htm

Society for Progressive Supranuclear Palsy
http://www.psp.org/

The Parkinson’s Institute
http://www.parkinsonsinstitute.org/movement disorders/progressive_supranuclear.html

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