Dementia with Lewy bodies is characterized by abnormal deposits of a protein called alpha-synuclein that form inside the brain's nerve cells.

These deposits are called "Lewy bodies" after the scientist who first described them. Lewy bodies have been found in several brain disorders, including dementia with Lewy bodies, Parkinson's disease and some cases of Alzheimer's.

• Memory problems, poor judgment, confusion and other cognitive symptoms that overlap with Alzheimer's disease.
• Excessive daytime drowsiness.
• Visual hallucinations.
• Cognitive symptoms and level of alertness may get better or worse (fluctuate) during the day or from one day to another.
• Movement symptoms, including stiffness, shuffling walk, shakiness, lack of facial expression, and problems with balance and falls.
• In about 50 percent of cases, dementia with Lewy bodies is associated with a condition called rapid eye movement (REM) sleep disorder.
  • REM sleep is the stage where people usually dream.
  • During normal REM sleep, body movement is suppressed and people do not "act out" their experiences while dreaming.
  • In REM sleep disorder, movement is not blocked and people act out their dreams, sometimes vividly and violently.

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• There are no drugs currently approved by the U.S. Food and Drug Administration (FDA) specifically to treat dementia with Lewy bodies.
• Some experts believe this condition may have the best response of any dementia to Alzheimer drugs called cholinesterase inhibitors.
• If the movement symptoms are severe, medications used in Parkinson's disease may be considered.
• Antipsychotic drugs should not be used in Lewy body dementia.
  • Individuals with Lewy body dementia are extremely sensitive to these drugs, which are sometimes used to treat hallucinations or behavioral symptoms of dementia.

More information

National Institutes of Neurological Disorders and Stroke
Dementia with Lewy Bodies Information Page
www.ninds.nih.gov
Information from one of the National Institutes of Health (NIH).

Mayo Clinic
Ask a Nervous System Specialist: What is dementia with Lewy bodies?
www.mayoclinic.org
This feature is from the Ask a Specialist section of the Mayo Clinic's consumer health information Web site.

Lewy Body Dementia Association, Inc.
www.lewybodydementia.org
A nonprofit organization providing information and assistance to individuals with the disease, caregivers and medical professionals.

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